Peter H. Siegel
Visiting Associate: Engineering and Applied Science
|Link to IEEE Transactions on Terahertz Science and Technology|
|If you wish to be considered for review board membership or to help out with the THz journal in any way please email Peter Siegel|
Background and Philosophy: Dr. Siegel’s research specializes in the invention, development and delivery of a wide range of specialized sensor and source devices, components, and instruments spanning the frequency range between 100 and 10,000 GHz which includes the millimeter, submillimeter and far infrared wavelength regimes: the terahertz bands. Emphasis is placed on a cross disciplinary approach which brings together a diverse range of backgrounds and skills that can be directly applied towards progress in bridging the electronic and optical regimes, one of the last remaining technology gaps in the electromagnetic spectrum. Students and staff working with Dr. Siegel include electrical engineers, physicists, biologists and chemists from a wide range of backgrounds and countries. Research work is conducted both at Caltech and at the nearby Jet Propulsion Laboratory, where the emphasis is on Earth, space science and planetary applications of THz technology. Dr. Siegel has recently founded a small international consulting company, THz Global, through which he is continuing his THz research work in collaboration with an international team of colleagues with expertise that spans the full range of millimeter and submillimeter wave applications.
Over the past 26 years Dr. Siegel and his Submillimeter Wave Advanced Technology team at JPL and Caltech have developed and delivered critical sensor hardware for four space flight missions: NASA’s Upper Atmospheric Research Satellite Microwave Limb Sounder, the first instrument to directly measure the anti-correlation between chlorine monoxide build up and ozone depletion on a global scale; NASA’s Earth Observing System Aura Microwave Limb Sounder measuring a wide range of stratospheric molecular species involved in ozone depletion, global water distribution, climate change and pollution monitoring across the Earth and carrying the first THz heterodyne radiometer in space - 2.5 THz OH and water line receiver; the European Space Agency’s Microwave Instrument on the Rosetta Orbiter (MIRO), that recently rendezvoused with comet Churyumov-Gerasimenko and that measures nuclear temperature and out gassing rates of carbon monoxide, water, ammonia and methanol; and most recently the Heterodyne Instrument for the Far Infrared (HIFI) on the European Space Agency’s Herschel Space Telescope, an ambitious astrophysics mission recording thousands of molecular signatures between 300 and 1900 GHz in and around star forming regions and in external galaxies, as a means of understanding the composition and evolution of the universe.
In addition to Earth, planetary and space science, Dr. Siegel is interested in terrestrial applications of terahertz imaging and spectroscopy and has been actively pursuing several related initiatives in the health and biological sciences at Caltech as well as defense and security applications at both Caltech and JPL. The very first National Institute of Health program in the terahertz field, granted to Dr. Siegel in 2002, had the goal of developing high signal-to-noise imaging and spectroscopy instruments for disease diagnostics. A second THz NIH program to develop low loss terahertz waveguide for endoscopy applications has also been completed. A consortium proposal with Stanford University School of Medicine and ZOmega Inc. to apply this newly established terahertz frequency and time domain instrumentation to skin cancer, in the first US health science application of terahertz in a clinical environment was submitted, but not funded. Additional work on the thermal and non- thermal effects of millimeter and submillimeter-wave radiation on cellular systems was started in 2008. This work is being undertaken in conjunction with the Caltech biology division and a neurophysiologist, Dr. Victor Pikov, at the Huntington Medical Research Institute. Significant expansion of the biological science work at Caltech is planned for 2014/15 through US NIH initiatives. Emphasis is being placed on affecting and monitoring cell processes under high frequency, low power, RF exposure. A major goal is to use millimeter waves to stimulate cell membrane depolarization thereby allowing direct, non-contact control of chemical transport. Initial results have now provided the first definitive measurements of significant change in membrane permeability and action potential firing rates on ex vivo cortical neurons from rat pups and neural ganglia in the medicinal leech. Additional RF-bio work in 2015 will include millimeter wave monitoring and diagnosis for health applications. Work has already begun with animal experiments at 40 GHz and will continue under a Caltech patent in 2015.
Microwave-to-THz Applications in Biology and Biomedicine (Caltech and Huntington Medical Research Institutes): This research was funded under several prior NIH and internal grants and involves the use of microwave, millimeter and submillimeter wave technologies for biological and biomedical applications. Specifically Dr. Siegel has been developing and utilizing the RF instrumentation that was pioneered under his former NASA programs for disease diagnosis, measurements of tissue properties, enhancing contrast through common biomedical staining techniques, and most recently to the impact of THz radiation on cellular processes and real time monitoring of metabolic processes in the body. Current research is focused on non-invasive glucose monitoring at millimeter wavelengths.
THz Effects on Cellular Systems (Caltech/HMRI): This program attempts to quantitatively examine THz (and millimeter wave) radiation impact on cells and cellular processes. It blends biological, optical and RF instrumentation in a novel way to examine RF dosimetry effects while directly monitoring cell lines and will establish one of the first IR Raman/optical/RF test instruments for microscopic evaluation of thermal and chemical processes at the cellular level. The work is conducted with collaborator Dr. Victor Pikov, a neurophysiologist at the Huntington Medical Research Institutes. Additional work on non-invasive millimeter wave monitoring of metabolic processes is awaiting final patent filing and will be pursued through NIH funding in 2015.
Dr. Siegel is working in the millimeter wave MMIC lab in 362 Moore where he has epi-fluorescence inverted and upright microscopes, an incubator, and an RF exposure system for studying cell level responses and processes. Dr. Siegel also regularly accesses the Huntington Medical Research Institute animal facilities across from Huntington Hopsital, Pasadena, where he works with Dr. Victor Pikov on the millimeter wave bio applications. He frequently consults with and visits with former colleagues and friends from the JPL Submillimeter-Wave Advanced Technology team, which he founded in 1992, and which is currently managed by Dr. Imran Mehdi.
This series of technical articles highlights the careers of individuals who have made significant long term contributions to the field of Terahertz Science and Technology. They appear as the lead articles in each issue of the IEEE Transactions on Terahertz Science and Technology. Enjoy their wisdom and their insights!
David H. Auston - Working Collectively to Combine Complementary Knowledge, Perspectives and Talents (vol. 1, no.1, Sept. 2011)
Paul L. Richards - Working at the Edge - Transition Edge Sensors and the Edge of the Universe (vol. 1, no. 2, Nov. 2011)
Maurice F. Kimmitt - A Person Who Makes Things Work (vol. 2, no. 1, Jan. 2012)
Robert W. Wilson - The Foundations of THz Radio Science (vol. 2., no. 2, March 2012)
Richard J. Saykally - Water, Water Everywhere... (vol. 2, no. 3, May 2012)
Daniel R. Grischkowsky - We Search for Truth and Beauty (vol. 2, no.4, July 2012)
Thomas G. Phillips - The Sky Above, the Mountain Below (vol. 2, no. 5, Sept. 2012)
Frank C. DeLucia - The Numbers Count (vol. 2, no. 6, Nov. 2012)
Federico Capasso - Physics by Design: Engineering Our Way Out of the THz Gap (vol. 3, no. 1, Jan. 2013)
Koji Mizuno - 50 Years in Submillimeter-Waves: From Otaku to Sensei (vol. 3, no. 2, March 2013)
Manfred Winnewisser and Brenda Pruden Winnewisser - Equating Hamiltonians to Nature (vol. 3, no. 3, May 2013)
Philippe Goy - If You Agree with the Majority You Might be Wrong (vol. 3, no. 4, July 2013)
Fritz Keilmann - RF Biophysics: From Strong Field to Near Field (vol. 3, no. 5, Sept. 2013)
Sir John Pendry - Theoretical Physics for a Practical World (vol. 3, no. 6, Nov. 2013)
Shenggang Liu - China's Father of Vacuum and Microwave Electronics (vol. 4, no.1, Jan. 2014)
Thijs de Graauw - Intention, Attention, Execution (vol. 4, no. 2, Mar. 2014)
Tatsuo Itoh - Transmission Lines and Antennas, Left and Right (vol. 4. no. 3, May 2014)
Michael Bass - The THz Light at the End of the Tunnel (vol. 4. no. 4, July 2014)
Erik Kollberg - Instrument Maker to the "Stars" (vol.4 no. 5, Sept. 2014)
Robert J. Mattauch - Two Terminals are Sufficient (vol. 4, no. 6, Nov. 2014)
Hiromasa Ito - Generating THz Energy is Crystal Clear (vol. 5, no. 1, Jan. 2015)
Jun-Ichi Nishizawa - THz Shogun (vol. 5, no. 2, Mar. 2015)
Derek Humphery Martin - The Mesh that Helped Ensnare the Cosmic Microwave Background (vol. 5, no. 3, May 2015)
Paul F. Goldsmith - New Eyes for THz Astronomers (vol. 5, no. 4, July 2015)
Xi-Cheng Zhang - The Face of THz (vol. 5, no. 5, Sept. 2015)
ChemMatters, “Peter Siegel: Studying the Energy of the Universe,” an interview article for the American Chemical Society, Sept. 2002, pp. 6-7
NIH e-Advances, “Retooling a Research Career - From Engineering to Biology and Back,” an e-interview for the National Institute of Health, June 2006.
BioOptics World, "Can Neurons Sense Millimeter Waves, a feature article by Barbara Goode, February 2010
Institution of Engineering and Technology, interview and feature supplement article, Electronics Letters, Interview with Dr. Peter Siegel, Dec. 2010
Co-author of Best Paper of the Decade award, Indium Phosphide and Related Materials Conference, 1998
Keynote Lecture and Highlighted Article for an opening exhibit of the National Electronics Museum: “Sir Jagadis Chunder Bose: Traversing the Interdisciplinary Gap Between Physics and Biology,” November 2008.
125 professional staff and student hires
Supervisor of 1 Doctoral, 1 Masters, 2 Senior theses
PI or co-I on 65+ research programs totaling more than $60M spanning 25 years
1000+ pages of technical reports!
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Last updated May 2, 2012.